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A search of the PubMed public database, based on the adopted criteria, identified nine preclinical studies that validated the significance of DNA methylation as a THCA-specific biomarker, primarily in tissue and plasma samples (Table 1)

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[DOI] [PubMed] [Google Scholar] 197.Kundu N, Zhang S, Fulton AM

The enrollment criteria for this trial required painful neuropathic symptoms of the extremities consistent with small fiber neuropathy