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Am J Pathol 2003

Biogenic amines: signals between commensal microbiota and gut physiology

Upon ischemic injury in stroke, neuronal HMGB1 is abundantly released into the extracellular space, both by active secretion and passive release, to accumulate in the ischemic core of the acute phase and to activate resident brain immune cells, leading to the recruitment of mononuclear cells that further amplify inflammation (Singh et al., 2016)

For uptake studies, cells were treated with Cy5-labeled paclitaxome-2, AZEpaclitaxome-2, or AZOpaclitaxome-2 (2 g ml 1 DSPECy5) for 1 h at 37 C in pH 6.5 or 7.4 medium (10% FBS)

Nearly one-quarter of patients in the rTMS group achieved complete recovery within two weeks versus none in the control group