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Animal studies have found that calycosin can improve spatial studying and memory and up-regulate the expression of synaptic proteins and brain-derived neurotrophic factor (BDNF) in the hippocampus of diabetic rats, and this effect may be associated with up-regulation of SOD, GSH-Px levels and down-regulation of MDA levels through the regulation of PI3K/Akt/glycogen synthase kinase 3 (GSK-3) pathway (61)

While ABCG2 did not influence the toxicity of the compounds, the presence of iron enhanced the protective effect of ABCC1 in A431 cells against DpC (RR: 7.3 vs RR(Fe): 8.9) and significantly increased it in the case of COTI-2 (RR: 15.8 vs RR(Fe): 61.5

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doi: 10.14744/TurkPediatriArs.2020.65148, 16

Functional activities of Philippine wild strain of Coprinus comatus (OF Mll.: Fr.) Pers and Pleurotus cystidiosus OK Miller grown on rice straw based substrate formulation