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These cells can survive chemotherapy and regenerate tumors, resulting in treatment failure ( Tumor stem cells in HGSOC typically express specific markers such as CD133, ALDH, and OCT4, which are closely linked to tumor invasiveness and drug resistance

Immunostaining of brain slices from kainic acid-treated mice and 5xFAD mice Kainic acid treatment and preparation of sections Kainic acid or vehicle injections were performed in 3 month-old C57BL6/J mice as previously described 47