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Also, in the late phase of M1 macrophage polarization, lactate-derived lactylation of histone lysine residues as observed in conditions of hypoxia and bacterial challenges served as an epigenetic modification that directly stimulated the expression of homeostatic genes that have been traditionally associated with M2-like macrophages (Zhang et al., 2019)

Additionally, the best results are seen through consistency

168 Studies in experimental models have shown an association between AATD and oxidative stress

Shcheslavskiy, Elena V

observed that recombinant Treponema pallidum protein regulates the ROS/NF-B pathway through ER stress