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doi: 10.1016/j.expneurol.2019.113045 27 EelenG.de ZeeuwP.SimonsM.CarmelietP

Symptoms may depend on the age and genetic disposition of the individual, and also the length and severity of deficiency

Ayton S, Lei P, Duce JA, Wong BXW, Sedjahtera A, Adlard PA et al

However, under starvation cells increase production of mitochondrial-derived hydrogen peroxide, which has been shown to be partly dependent on the activation of class III PI3K (Scherz-Shouval and Elazar, 2007)