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As phytotherapeutic interventions span fractions within integrative frameworks, their compatibility with the Shoemaker Protocol depends not only on mechanistic alignment with biomarker pathology, but also on rigorous understanding of doseresponse relationships, metabolic liabilities, and contraindications

PloS One 6, e23776

Thus, further validation of our results through in vivo experiments and clinical practice is needed

Individuals may suffer lethargy, fatigue, despair, psychological lability, arthralgias, weight diarrhoea, loss, and anorexia

These conditions require treatment of the underlying cause rather than pathway modulation