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Free Radic Biol Med 30(11): 1191212

Journal of Cardiovascular Development and Disease, 11 (12), 377

293,294 Depleting macrophages or inhibiting their migration improves mechanical sensation and nerve function in animal models

Mitochondrial ROS Metabolism: Modulation by Uncoupling Proteins

We found that the injection of RESV reduced the changes caused by the STZ-induced stimulation of TRPV4, which in turn increased mechanical/thermal neuropathic pain, cytosolic Ca 2+ influx, TRPV4 current density, oxidants (lipid peroxidation, mitochondrial ROS, and cytosolic ROS), and apoptotic markers (caspase-3, -8, and -9)