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[3] Hyperpigmentation in B12 deficiency occurs as a result of (1) decreased levels of reduced glutathione which activates tyrosinase and results in increased melanin synthesis, (2) defect in transfer of melanin from melanocytes to keratinocytes resulting in pigment incontinence, (3) increased biopterin in B12 deficiency increases hydroxylated phenylalanine which results in hyperpigmentation

Mascarenhas R, Gouda H, Ruetz M, Banerjee R

The decision comes down to where you are in your dosing protocol

Vascular endothelial growth factor is an autocrine growth factor for hair dermal papilla cells

Every Instagram workout reel (on my feed, at least) now seems to be soundtracked by Tylas Chanel