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Introduction Atopic dermatitis (AD) is one of the most common chronic inflammatory cutaneous diseases with a relapsing-remitting course characterized by pruritus, dry skin, and eczema lesions ( Among all of the inflammatory cytokines, TNF- has gained a lot of attention due to its multiple effects in promoting cells death, including receptor-interacting protein 1 (RIP1)-independent apoptosis, RIP1-dependent apoptosis (RDA), and necroptosis ( As the main bioactive component of tea polyphenols, the health benefits of epigallocatechin-3-gallate (EGCG) have been widely used in treating a wide range of diseases, based on its anti-inflammatory and antioxidant properties ( However, the low bioavailability, instability, and cytotoxicity at a large dose limited the clinical application of EGCG

Since progesterone helps regulate testosterones effects on hair follicles, its imbalance can contribute to hair loss

For example, transdermal microneedles loaded with allopurinol bypass hepatic metabolism, reducing first-pass effects and enabling sustained release (Wang et al., 2025)