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It also increased the expression of CD38 at the mRNA level by activating the Janus kinase signal transducer and transcription activator (JAK-STAT) pathway ( The recovery of CD38-deficient mice after closed head injury (CHI) was significantly lower than that of wild-type (WT) mice, and the object recognition ability of CD38-deficient mice was significantly lower than that of the WT mice

Additionally, flavonoids modulate key enzymes such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, xanthine oxidase, and cyclooxygenase-2, which are major sources of ROS involved in chemotherapy resistance (Passaniti et al., 2022