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Weeks Tirzepatide dose Notes 14 2.5 mg Initiation only (not for glucose/weight effect) 58 5 mg First maintenance option 912 7.5 mg Increase as tolerated 1316 10 mg Maintenance option 1720 12.5 mg Increase as tolerated 21+ 15 mg (max) Maximum maintenance dose These steps follow the Mounjaro FDA label and Zepbound FDA label

GHK-Cu generally shows better thermal stability in aqueous solutions, while AHK-Cu may require antioxidant systems for long-term formulation stability

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These effects result in very significant weight loss (15-20% of initial body weight), i.e., of the same order of magnitude as that obtained by bariatric surgery

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