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Description

The safety of IGF-1 is sometimes questioned, but this hormone is very safe, especially based on the fact that it is produced in the liver

It suppresses ECM degradation, counteracts RSL3 mediated inhibition of GPX4, increases intracellular GSH levels and the GSH/GSSG ratio, reduces MDA content, and inhibits activation of the MAPK/NF-KB pathways, thereby protecting chondrocytes from ferroptosis (156)