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Support for this hypothesis comes from Bauman et al

Once in the nucleus, it binds to specific transcription factors and DNA elements particularly antioxidant response elements (ARE) that are regulated by the stress-responsive factor NRF2. Through this mechanism, MOTS-c can turn on a suite of stress-defense and metabolic genes that help cells adapt to high-fat stress or insulin resistance

CAS Number: 68-19-9 (Cyanocobalamin reference form) Molecular Formula: C63H88CoN14O14P Molecular Weight: ~1355.38 g/mol Compound Classification: Naturally occurring cobalt-containing corrinoid vitamin Specifications Form: Aqueous solution Concentration: 1000 g/mL (nominal) Vitamin B-12 Volume: 10 mL Filtration: 0.2 m sterile membrane Preservative: 0.9% Benzyl Alcohol Container: Sterile glass vial Appearance: Red solution Purity: Manufactured to defined specification (98% assay cyanocobalamin

Such observations indicate that NNMT plays a beneficial role in regulating gluconeogenesis in hepatocytes

doi: 10.1001/archinte.1965.03860150029006