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For example, bone spurs that develop in the lumbar spine are likely to cause symptoms experienced by the lower body, while bone spurs that develop on a knee can make it difficult to fully extend and bend the leg

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[DOI] [PubMed] [Google Scholar] 63.Przyborowski K., Wojewoda M., Sitek B., et al

The cytokines IL-12 and IL-23 play a central role in T-cell-mediated regulation, and their use as therapeutic targets has highlighted their importance to host defense and inflammatory disease [66,67,68]