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Impact of the timing of morphine administration on lipopolysaccharide-mediated lethal endotoxic shock in mice

The invariant cis -Pro residue is located in the loop region before 3 and is thought to be implicated in the maintenance of the enzyme fold rather than playing a role in the enzymatic reaction (Figure 3A) (Allocati et al., cis -proline is hydrogen-bonded to the backbone of CysGS (cysteine residue of glutathione) (Figure 3A)

These findings correlate with data suggesting that the improved GSH level results in stress tolerance as seen in Arabidopsis 29

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