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The polyphenols ability to cross the blood-brain barrier facilitates direct neural tissue intervention, promoting neurogenesis, enhancing synaptic plasticity, and potentially modulating neuroinflammatory responses

In ME/CFS, pro-inflammatory cytokines such as IL-1, IL-4, IL-5, TNF-, IL-10, IFN-, IL-12, and lymphotoxin- (LTA) are increased

However, ongoing studies have revealed that the multifaceted role of IFNs in the antitumor response during anti-PD treatment involves not only the classical JAK-STAT signaling pathway but also various noncanonical pathways that can lead to diverse outcomes, contributing to either tumor progression or tumor regression under certain conditions