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Liquid-liquid phase separation is affected by HSP70/HSP40 interaction as well as protein clearance does (cytosolic translocation of TDP-43) (Yeo et al., 2025)

First, ferritin can reprogram the immune microenvironment of tumors, and similar mechanisms may also be operative in the AML-supporting bone marrow microenvironment where various immunocompetent cells (including macrophage subsets) seem to support the leukemic cells [53,54,68,71,72,73,125]

J Thorac Cardiovasc Surg 119(6):1126-32, 2000

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However, long-term use of irreversible MAO inhibitors has been associated with compensatory mechanisms, such as the upregulation of diamine oxidase (DAO), 36 which can limit long-term efficacy