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Furthermore, our lab has previously shown that individuals with T2DM have lowered levels of GSH due to decreased levels of both GCL and GSS protein compared to healthy subjects (Lagman et al., 2015)

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doi:10.1093/nar/28.1.292 Nocek B, Evdokimova E, Proudfoot M, Kudritska M, Grochowski LL, White RH, Savchenko A, Yakunin AF, Edwards A, Joachimiak A (2007) Structure of an amide bond forming F420:-glutamyl ligase from Archaeoglobus fulgidus a member of a new family of non-ribosomal peptide synthases