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Description

SAMe depletion in AD animal models and in vitro has been shown to perturb DNA methylation with resultant increases in the expression of Amyloid Beta Precursor Protein (APP), Presenilin-1 (PS1) and Beta-Secretase 1 (BACE1) genes, stimulating A production and neurodegeneration (13-16)

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Perturbations in the ER-localized zinc transporter ZIP7 further illustrate the pathological consequences of ER zinc imbalance

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Tissue-specific regulation of cytochrome c by post-translational modifications: respiration, the mitochondrial membrane potential, ROS, and apoptosis

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M.DufortD.GrovesA

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[PMC free article: PMC2756298] [PubMed: 19664690] (Extensive review of the biochemistry of ALA and the basis for its suspected antioxidant activities and their possible role in diabetes and polyneuropathy)

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