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Treatment of psoriasis with 6-aminonicotinamide, which inhibits the 6PGD reaction in the oxPPP, decreased itching and cleared some lesions 133

Interstitial fibrosis further induces ischemia and hypoxia by impairing capillary to tubule diffusion, creating a vicious cycle and exacerbating renal injury (43)

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Hypothesizing that the compounds suppress metabolism and therefore block viral gene expression, adding the inhibitors 2 h after infection, when entry has occurred, should not have a dramatic negative impact on their antiviral activity