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The lactylation equilibrium is maintained by deacetylases such as HDAC3, which remove lactylation marks from diverse substratesincluding site K673 of the DNA repair protein MRE11thereby finely regulating cellular processes including DNA repair and gene transcription [24]

The present study was supported by MUNI/A/0846/2011, NanoBioMetalNet CZ.1.07/2.4.0 0/31.0 023, MSMT 6215712402 and CEITEC CZ.1.05/1.1.00/02.0068

Management strategies include smaller, more frequent meals rather than large ones, avoiding high-fat meals that slow gastric emptying further, staying upright for at least 30 minutes after eating, and using ginger or peppermint tea as natural anti-nausea agents

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