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Journal of Clinical Endocrinology and Metabolism 91(3):799-805. [doi.org]

On examination, scaly patches of erythema were seen on both cheeks, going into the nasolabial folds

Because research-grade material is not manufactured to sterile-injectable pharmaceutical standards, sterility and endotoxin content are not guaranteed by the supplier the way they would be for an approved parenteral drug a point that belongs squarely in the safety discussion below

Cooper BA, Rosenblatt DS

This includes compounds such as nitrogen mustards, which have the property to alkylate DNA after further transformation: TLK286 (canfosfamide, TELCYTA TM ) and analogs (Lyttle et al., 1994