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Research studies, conducted in several in vitro and in vivo animal and clinical models have shown that these agents are active in treatment of abnormal cellular metabolism induced by mitochondrial inhibitors, or those caused by L-carnitine deficiency or insufficiency created by iatrogenic factors (e.g., valproate, pivalic acid)

doi: 10.15252/embr.202051921 115 MutluGMGreenDBellmeyerABakerCMBurgessZRajamannanNet al

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Another study found a higher prevalence of C677T polymorphism in BD patients than healthy subjects, while patients with BD with early onset carried one copy of the T allele 62

doi: 10.1021/jacs.8b08014