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Similarly, after a stroke or traumatic brain injury, acute inflammation in the brain can cause secondary damage to neural tissue [242]

A small uncontrolled open-label trial reported that receiving 120 mg pine bark extract, 60 mg vitamin C, and 30 IU vitamin E daily for 3 months in migraine patients led to a significant reduction in the headache frequency, severity, and migraine disability (91)

Some older research suggests that vegan collagen could be made using genetically modified yeast and bacteria

It remains to be seen whether properly conducted randomized clinical trials will strengthen or weaken these associations

Proc Natl Acad Sci U S A 113:38443849