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Given the pivotal roles the pathophysiology and signaling pathways play in ischemic stroke, numerous therapeutic approaches have been explored in both experimental and clinical studies, and several of them have been demonstrated to be effective in treatment of ischemic stroke (Table 2)

doi: 10.3390/metabo12080675 116 LonardoAMantovaniALugariSTargherG

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Brumaghim JL

For example, glutathionea powerful tripeptide antioxidantis completely broken apart by stomach peptidases into individual amino acids, losing its therapeutic glutathione form