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Simulations suggested that this microsphere formulation could allow for once-monthly human dosing while maintaining effective drug levels, potentially reducing adverse side effects

Therefore, a thorough investigation is crucial, especially in patients experiencing significant pain or bleeding

Moreover, Mn-deficient diets exacerbate colitis in mice, whereas Mn supplementation restores epithelial integrity and reduces mucosal injury (Choi et al., 2020)

Ethics declarations Ethics approval and consent to participate The Ethics Committee of The Third Hospital of Qinhuangdao approved all experimental protocols

TORC2, a coactivator of cAMP-response element-binding protein, promotes Epstein-Barr virus reactivation from latency through interaction with viral BZLF1 protein