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While mTORC2 primarily promotes cell proliferation and survival through the phosphorylation of AKT, many tumors need mTORC1 to maintain their ability to control protein synthesis and cell growth, as well as to coordinate nutrient and energy supply to ensure that they undergo unrestricted cell division (103)

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Bcl-2 family proteins in breast development and cancer: could Mcl-1 targeting overcome therapeutic resistance

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Combining both approaches often delivers superior results