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In CRC, PHGDH is markedly upregulated: Cullin 4A (Cul4A)-mediated PHGDH ubiquitination enhances its stability and activity, elevating SAM levels to promote metastasis via SETD1A-dependent histone methylation of cell adhesion genes (191)

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Phase I involves a transfer of a hydroxyl, a carboxyl, or an amino group to the toxic compound, which is often mediated by the cytochrome P450 enzymes