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TBI-induced neuroinflammation further intensifies this metabolic reprogramming, with activated microglia releasing pro-inflammatory factors like IL-6 and TNF, enhancing glycolysis while suppressing OXPHOS through TLR signaling pathways (190)

Motor neuron vulnerability and resistance in amyotrophic lateral sclerosis

Importantly, despite recent research indicating distinct findings regarding the 40 Hz effect, particularly concerning amyloid load in AD 21,22 , multiple studies in both mouse models and humans have consistently affirmed the beneficial effects of GENUS on disease pathology 18,19,23,24,25,26,27,28,29,30