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Description

J Exp Med (2022) 219(1):e20211140

doi: 10.3390/nu13082851, 43

10.1002/art.27559

Drugs that trigger intrinsic DILI are frequently lipophilic, allowing them to pass through the liver cells fatty membrane easily

In all Chi structures, the pocket is lined with positively charged residues that may interact with negatively charged phosphate groups, suggesting a common binding site for phospholipid-like molecules