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Surprisingly, abnormal sphingolipid metabolism has been shown to play a key role in the pathogenesis of PD [173]

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Glutathione conjugation also contributes to the binding of 1,2-dibromoethane to DNA, and an S- [2-(N 7 -guanyl)ethyl] glutathione adduct has been identified (Ozawa & Guengerich, 1983

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