Further research is needed to solve this problem, although it has been reported that in neurodegenerative diseases, the presence of oxidative stress in PBMCs or red blood cells is associated with oxidative stress in other cells, including the RGCs, endothelial cells and astrocytes, which support neural cells and share the same micro-environment.[18, 4549] Previous research suggests that redox status in PBMCs could be associated with vascular endothelial function, and that altered redox status could lead to abnormal vascular autoregulation in diabetes mellitus and cardiovascular diseases.[24] [25] Endothelial cells damaged by oxidative stress reduce their production of NO, which regulates hemodynamics.[50] This change in NO action could also be related to glaucoma pathogenesis.[51] In this study, we found a relationship between low redox status in the PBMCs and vasoconstriction, as evaluated with ATI in the ONH, indicating that redox index in the PBMCs might be a biomarker of the autoregulation system, which is regulated by endothelial cells in the ONH
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doi: 10.21873/anticanres.11186 215 ChoiARJee JoMJungMJSik KimHYoonS
KD plays an important role in reducing the frequency and severity of migraine attacks in both adolescents and adults (115), and it has also been shown to improve sleep disorders (116)
These functions are primarily carried out by two types of cells that are involved in the recognition of antigen: (1) the thymus-dependent or T lymphocytes, which participate in cellular responses against intracellular pathogens, organ transplants, and malignant cells (2) the bone marrow or bursal-dependent B lymphocytes, which provide humoral immunity, i.e., antibody-mediated immunity against extracellular pathogens, their toxins, and other environmental substances
