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The impurity content of reduced glutathione is as follows: impurity A Chemical name: bis (L-gamma-glutamyl-L-cysteinylglycine) disulfide (L-oxidized glutathione) Structural formula (xvi): the molecular formula is as follows: C20H32N6O12S2 Molecular weight: 612.63 Impurity B Chemical name: l-cysteinylglycine Structural formula (xvi): the molecular formula is as follows: C5H10N2O3S Molecular weight: 178.21 Impurity D Chemical name: (5S) -2-pyrrolidone-5-carboxylic acid Structural formula (xvi): the molecular formula is as follows: C5H7NO3 Molecular weight: 129.11 Compatibility test results In combination with domestic common solvents for injections, 0.9% sodium chloride injection, 5% glucose injection, 10% glucose injection and water for injection are selected for compatibility experiments under normal temperature conditions

CD38 was also considered a major contributor to the acquired resistance to PD1/PDL1 blockade, causing CD8+ T-cell suppression