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Lemley CO, Camacho LE, Vonnahme KA

In addition, bacteria-derived LPS increases Toll-like receptor 4 (TLR4) activity and activates downstream NF-B signaling to promote inflammation and barrier dysfunction 69

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In a Brazilian RCT with 67 participants suffering unipolar and bipolar depression, NAC dramatically reduced CRP throughout the course of 12 weeks when compared to a placebo