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Eosinophil granules contain proinflammatory proteins (major basic protein [MBP], eosinophil cationic protein [ECP], eosinophil-derived neurotoxin [EDN], eosinophil peroxidase [EPO], etc.), PAF, and hydrogen peroxide and superoxide anions, which are the main weapons used to eliminate parasites (especially helminths), as well as bacteria (including mycobacteria)

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Under normal conditions, HIFs are hydroxylated by the hydroxylase family in an oxygen-dependent manner, which leads to a substantial reduction in the transcriptional activity of HIFs, whereas under hypoxic conditions, the hydroxylate activity is inhibited, and HIFs accumulate in the cytoplasm