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The anti-inflammatory systemPI3K/Akt signaling pathway has been suggested as the partial potential mechanism of AST on DED via downregulating the expression of HMGB1 (Li et al., 2020)

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Early intervention with senomorphic compounds could delay the onset of age-related diseases by modulating senescence in at-risk individuals, potentially leading to an extension of healthspan (the period of life spent in good health).35,130 This preventive approach could be especially beneficial for populations with genetic predispositions to certain conditions or those already showing early signs of aging-related decline