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The complex pathophysiology and heterogeneity of the disease raises the speculation that combined treatment will be required for many patients

Pneumonia caused by drug-resistant bacteria is harder to treat and may lead to longer illness and greater risk of death (Bosso 2011)

2022;61(14):e202116983

Paeonol can reduce the expression of pyroptosis-related proteins (NLRP3, ASC, caspase-1, N-GSDMD, IL-1, IL-18, and tumor necrosis factor-) in SCI rats by inhibiting NLRP3 inflammasome formation and promoting BV-2 cell polarization to M2 (Zhao et al., 2022a)