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The efficacy of nicotinamide riboside, a precursor of NAD, in preventing CIPN is under investigation (NCT04112641)

HFF-1 cells maintained in a T-25 cell culture flask (Corning, United States) at 37C in a 5% (v/v) CO 2 atmosphere and harvested at 90% confluence using 0.12% trypsin-EDTA

Overall, NRF2 plays a crucial cellular protective role through the sensing of oxidative stress, nuclear translocation, binding to AREs, and the regulation of the expression of antioxidant and detoxification enzymes

Notably, human GST T1-1 also has negligible catalytic activity with CDNB 20

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