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The purpose of this replacement therapy is to replace substances that aren't working properly in your body with ones that are more effective

However, clearance can markedly affect the extent of availability because it determines the extraction ratio (equation [8a])

Pediatr Endocrinol Rev

Accessed 12/3/2020, Lepcha A, Amalanathan S, Augustine AM, Tyagi AK, Balraj A

MVP scoring policies are intended to reduce reporting requirements in MVPs to incentivize MVP participation and allow MVP Participants to report on a smaller, more cohesive subset of measures and activities that are relevant to a given clinical topic, condition, or episode of care, while still driving quality (86 FR 65419 and 65420)