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However, the binding of VEGF-A to VEGFR-2 promotes mitosis and the permeability of vascular endothelial cells, leading to angiogenesis, and serves as the principal regulatory mechanism in angiogenesis (31)

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For example: Endogenous GHRH has a half-life of ~515 minutes Native GLP-1 is broken down in under 2 minutes Thats why natural peptides are rarely used directly in therapeutics theyre too unstable

doi: 10.1016/j.pnpbp.2020.109951 444 R.a.P