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Mechanics-activated fibroblasts secrete IL-18 which is dependent on Notch3 signaling To understand the molecular mechanism underpinning fibroblast-mediated ILC conversion, we performed bulk RNA-sequencing on primary lung fibroblasts cultured on matrix gels, and identified upregulated and downregulated transcripts, respectively, in stiff matrix-cultured fibroblasts (Fig

However, specific phage factors that counter-act many other bacterial defense systems remain elusive, especially, in the context of phage infections in the wild where multiple defenses often operate together 6,13