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458 While five cases of grade 3 toxicity were observed (including anorexia, increased serum aspartate aminotransferase, increased serum alkaline phosphatase, fever, and fatigue), no dose-limiting toxicities were reported

[ [PMID: 26481148]

Moreover, it has also been shown that TdNs can interfere in the ischemic cascade that involves excitotoxicity, apoptosis, and oxidative stress, and confer neuroprotection to the neuronal SH-SY5Y cells