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10 Studies have shown that MDA levels are increased in various diseases, such as cancer, 11 diabetes, 12 chronic obstructive pulmonary disease (COPD), 13 hypertension (HT), 14 ARDS, 15 atherosclerosis, and neurodegenerative diseases such as Alzheimers and Parkinsons, compared to healthy individuals

Diabetes mellitus decreases hippocampal release of neurotransmitters: an in vivo microdialysis study of awake, freely moving rats

GT-activated prodrugs and potential nephrotoxicity Gamma-glutamyl transferase being the initial and limiting step in GT-activated prodrugs processing and because GT is highly expressed on the luminal surface of the proximal tubules in the kidney, potential nephrotoxicity could have been a limitation in the usage of this class of compound when administered systematically

doi: 10.1016/j.ejmech.2014.10.047 52

The resulting modulation of cheA activity influences cheY phosphorylation, which determines its motor-binding capability