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What substance depletion causes hepatic necrosis from acetaminophen overdose ? acetaminophen hepatic glutathione Full article: Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease Acetaminophen Toxicity: How Genetic Susceptibility Acetylcysteine for Acetaminophen Poisoning New England Journal of Medicine NAC Benefits: Glutathione Replenishment in Tylenol Toxicity Cases Reducing the effects of drug toxicity on glutathione metabolism ScienceDirect
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