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Abnormal NLRP3 inflammasome activation and excessive IL-1 secretion is the major reason of CAPS, and has been demonstrated in three clinical subtypes: neonatal-onset multisystem inflammatory disease (NOMID), Muckle-Wells syndrome (MWS), and familial cold autoinflammatory syndrome (FCAS)

Treatment Duration Some peptides are used short-term (4-12 weeks) for specific goals like injury recovery

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Mutant ATXN3 aggregation has been also associated to dysregulation of the microRNA (miRNA) machinery [127,128,129]

Stress stimuli or inflammatory factors can activate JNK kinase, increasing mitochondrial membrane permeability and initiating a caspase cascade reaction (Yuan et al., 2023)