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Its compact sequence and selective receptor activity make it a common tool in endocrine-focused peptide studies

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On the other hand, the lack of a significant anxiolytic effect with GABA treatment raises questions about its bioavailability or receptor interactions in the specific context of the EPM test, possibly due to differences in the route of administration, dosage, or the animal models specific pathology

In FXS, CGG repeat expansions in the FMR1 gene lead to the loss of FMRP, impairing the translation of GABAA receptor mRNAs, particularly the GABAA 5 subunit, reducing receptor density in the amygdala and nucleus accumbens, resulting in delayed language development and autistic-like behaviors (138)