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In the brain of WT animals treated with vB12 versus PBS, we found 1831 DEGs (Figs 5A and S4C, Table S2), and in Tbx1 +/ animals treated with vB12 versus PBS, we found 1,639 DEGs (Figs 5A and S4B, Table S2)

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Additionally, the regulatory mechanisms between other pathways or protein receptors mediating mitophagy and mitochondrial biogenesis require further investigation