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With permanent vessel obstruction, once the therapeutic effect begins, the beneficial action proceeds without further reappearance of the adverse effects of vessel obstruction (Duzel et al., 2017

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Most of cases are simple and do not require treatment, but severe cases may require regular blood transfusions, removal of excess iron, and folic acid supplements

The supplement was well-tolerated, with few side-effects, although for a few participants their individually titrated dose was lower than originally prescribed