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The PINK1/parkin pathway is a key mediator of mitophagy (54), effectively removing damaged mitochondria and avoiding excessive ROS production (5558)

Furthermore, L-carnitine as a potent antioxidant can decrease oxidation of purine and pyrimidine bases, breakage of DNA single and double strands, DNA fragmentation and protamine deficiency and maintain DNA integrity during cryopreservation by ROS reduction (78)